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Telomerase, an enzyme that maintains telomeres and endows eukaryotic cells with immortality, was first discovered in tetrahymena in 1985. In 1990s, it was proven that this enzyme also plays a key role in the infinite proliferation of human cancer cells. Now telomere and...
Editeur :
Humana
Parution :
2009-03-18
Collection :
Cancer Drug Discovery and Development
ePub
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The evolution in our understanding of opioid receptors and their subtypes is in- mately linked to the development of new pharmacological treatments for diseases/ disorders as diverse as addiction, self-injurious behavior, pain, cancer, infl- mation, eating disorders,...
Editeur :
Humana
Parution :
2009-03-12
Collection :
Contemporary Neuroscience
ePub
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There are unique challenges in the formulation, manufacture, analytical chemistry, and regulatory requirements of low-dose drugs. This book provides an overview of this specialized field and combines formulation, analytical, and regulatory aspects of low-dose...
Editeur :
Wiley
Parution :
2009-03-04
PDF
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Destined to become every regulatory director's essential desktop companion Professionals working to submit major documents to the Food and Drug Administration (FDA) are guaranteed to encounter numerous unexpected and daunting hurdles. Guidebook for Drug Regulatory...
Editeur :
Wiley
Parution :
2009-02-23
PDF
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Drug Efficacy, Safety, and Biologics Discovery: Emerging Technologies and Tools covers key emerging technologies in pharmaceutical R & D and how they have substantially impacted (or are currently impacting) drug discovery. The cross-disciplinary collaborations implicit...
Editeur :
Wiley
Parution :
2009-01-28
Collection :
Wiley Series on Technologies for the Pharmaceutical Industry
PDF
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Cisplatin, the first member of the family of platinum-containing chemotherapeutic agents, was discovered by Barnett Rosenberg in 1965 and approved by the FDA for marketing in 1978. After 30 years of use in the clinic, cisplatin remains a central element of many...
Editeur :
Humana
Parution :
2009-01-09
ePub
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The serious nature of cardiovascular adverse drug reactions occurring in patients makes assessment of a drug's cardiac safety profile a high priority during both development and post-approval monitoring. Integrated Cardiac Safety provides necessary guidance and...
Editeur :
Wiley
Parution :
2008-11-26
PDF
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An important reference which provides an overview of the current and recently introduced methodologies for testing the immunotoxic risks in drug candidates Helps readers understand the significance of the methods and approaches to immunotoxicology testing Aids drug...
Editeur :
Wiley-Interscience
Parution :
2008-11-21
PDF
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This book answers the questions about the process and costs of pharmaceutical R & D in a compelling narrative focused on the discovery and development of important new medicines. It gives an insider's account of the pharmaceutical industry drug discovery process, the...
Editeur :
Wiley
Parution :
2008-11-03
PDF, ePub
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Early characterization of toxicity and efficacy would significantly impact the overall productivity of pharmaceutical R&D and reduce drug candidate attrition and failure. By describing the available platforms and weighing their relative advantages and disadvantages,...
Editeur :
Wiley
Parution :
2008-11-03
PDF
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The reader will be introduced to various aspects of the fundamentals of nanotechnology based drug delivery systems and the application of these systems for the delivery of small molecules, proteins, peptides, oligonucleotides and genes. How these systems overcome...
Editeur :
Springer
Parution :
2008-10-29
Collection :
Biotechnology: Pharmaceutical Aspects
ePub
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Edited by two experts working at the pioneering pharmaceutical company and major global player in hormone-derived drugs, this handbook and reference systematically treats the drug development aspects of all human nuclear receptors, including recently characterized...
Editeur :
Wiley-VCH
Parution :
2008-09-08
Collection :
Methods & Principles in Medicinal Chemistry
PDF
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This first comprehensive survey to cover all pharmaceutically relevant topics provides a comprehensive introduction to this novel and revolutionary tool, presenting both concepts and application examples of biosimulated cells, organs and organisms. Following an...
Editeur :
Wiley-VCH
Parution :
2008-09-08
PDF
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Since the development of the NMR spectrometer in the 1950s, NMR spectra have been widely used for the elucidation of the 2D structure of newly synthesized and natural compounds. In the 1980s, the high-resolution NMR spectrometer (> 300 Mhz) and 2D experiments were...
Editeur :
Wiley-Blackwell
Parution :
2008-07-11
PDF
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A step-by-step, integrated approach for successful, FDA-approved combination drug products Using a proven integrated approach to combination drug development, this book guides you step by step through all the preclinical, clinical, and manufacturing stages. Written...
Editeur :
Wiley-Interscience
Parution :
2008-06-09
PDF
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Offers a social view of the activities leading to the timely patient access to medicines including: drug research, drug production, drug distribution, drug prescribing, drug information and drug control Provides theoretical models to enable pharmacists to understand...
Editeur :
Wiley
Parution :
2008-05-27
PDF
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Antibiotic Resistance: Origins, Evolution, Selection and SpreadChairman: Stuart B. Levy, 1997 Over the last 50 years, the rapid increase in the use of antibiotics, not only in people, but also in animal husbandry and agriculture, has delivered a selection unprecedented...
Editeur :
Wiley
Parution :
2008-04-30
Collection :
Novartis Foundation Symposia
PDF
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Nicotine is considered to be the main agent in the maintenance of the tobacco smoking habit and is largely responsible for the behavioral and physiological responses to the inhalation of tobacco smoke. This work presents advances made in the elucidation of the action of...
Editeur :
Wiley
Parution :
2008-04-30
Collection :
Novartis Foundation Symposia
PDF
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Proposed changes in practice legislation will allow podiatrists to prescribe a limited range of drugs and dressings. It is therefore now imperative that students and practitioners understand pharmacology. Not only the mechanisms of action of drugs, but also their...
Editeur :
Wiley-Blackwell
Parution :
2008-04-30
PDF
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A simple and systematic guide to the planning and performance of investigations concerned with health and disease and with health care Offers researchers help in choosing a topic and to think about shaping objectives and ideas and to link these with the appropriate...
Editeur :
Wiley
Parution :
2008-04-30
PDF, ePub
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